Electrochemistry
According to Sigma-Aldrich, DFES-Na sold out of stock within 1 week of being listed, and due to the incredible demand, they are targeting multi-kilo quantities. Metric tons of DFES-Na will likely be needed in the next 10 years. This is, of course, exciting news for us but we would also like this blog post to be exciting for you as well. So, we have put up another video. This one is about Qianghui (first author of the paper describing DFES-Na) running a difluoroethylation reaction and hopefully after watching this video, you will be running your own difluoroethylation, too!
- Making C–c Bonds With The Simplicity Of Making Amide Bonds
Despite all of the wonderful advances in organic synthesis, amide-bond formation is still the most widely used reaction among those making medicines. This truth has led some to declare their embarrassment and depression. Medicinal...
- Diversinate Update
Since our first report in 2011 on the trifluoromethylation of heterocycles, sulfinate chemistry has been demonstrated to be a useful tool for drug discovery. The lab extended this chemistry beyond trifluoromethyl radicals to a whole host of...
- Back To Heterocycles!
I guess this blog entry could be called "The Portable Chemist's Consultant Part 5” (see Part 4 here)First off, we have new book updates (latest version 2.6.1), as listed in iTunes and on the book's website. In about ~2 years from the first...
- Functionalized Olefin Cross-coupling
Figure 1. Functionalized olefin cross-coupling at a glance. The last paper of the year from the inner depths of our lab has made its way out earlier today. It’s the bigger brother of our reductive olefin coupling paper from January. In a nutshell, reductive...
- Experiments With Googling
[Disclaimer - I couldn't think of any good images for this blog post, so to liven it up a bit here are a few things you can use: 1) An ASCII game you can play in your browser that is quite fun - pro tip - let it run in the background while you're...
Electrochemistry
The difluoroethylator?
Over the past few years our laboratory has become interested in the radical functionalization of heterocycles. This started with arylboronic acids as radical precursors but recently developed into alkylsulfinate chemistry. The latest addition to our list of commercialized reagents is sodium difluoroethanesulfinate (DFES-Na), a difluoroethylating agent.
According to Sigma-Aldrich, DFES-Na sold out of stock within 1 week of being listed, and due to the incredible demand, they are targeting multi-kilo quantities. Metric tons of DFES-Na will likely be needed in the next 10 years. This is, of course, exciting news for us but we would also like this blog post to be exciting for you as well. So, we have put up another video. This one is about Qianghui (first author of the paper describing DFES-Na) running a difluoroethylation reaction and hopefully after watching this video, you will be running your own difluoroethylation, too!
- Making C–c Bonds With The Simplicity Of Making Amide Bonds
Despite all of the wonderful advances in organic synthesis, amide-bond formation is still the most widely used reaction among those making medicines. This truth has led some to declare their embarrassment and depression. Medicinal...
- Diversinate Update
Since our first report in 2011 on the trifluoromethylation of heterocycles, sulfinate chemistry has been demonstrated to be a useful tool for drug discovery. The lab extended this chemistry beyond trifluoromethyl radicals to a whole host of...
- Back To Heterocycles!
I guess this blog entry could be called "The Portable Chemist's Consultant Part 5” (see Part 4 here)First off, we have new book updates (latest version 2.6.1), as listed in iTunes and on the book's website. In about ~2 years from the first...
- Functionalized Olefin Cross-coupling
Figure 1. Functionalized olefin cross-coupling at a glance. The last paper of the year from the inner depths of our lab has made its way out earlier today. It’s the bigger brother of our reductive olefin coupling paper from January. In a nutshell, reductive...
- Experiments With Googling
[Disclaimer - I couldn't think of any good images for this blog post, so to liven it up a bit here are a few things you can use: 1) An ASCII game you can play in your browser that is quite fun - pro tip - let it run in the background while you're...