Electrochemistry
Last month the team at Eisai responsible for the commercial scale synthesis of Halaven (easily the most complex drug molecule produced entirely by chemical synthesis) published a series of papers (theres three links there) detailing the development from the medchem route to process. While these papers are a must read from the standpoint of using total synthesis to solve a supply need, this post is only peripherally related.
Early on in the synthesis of one of the pieces of the western half of the molecule the group does a chromatographic resolution of a racemic alcohol using 'simulated moving bed chromatography'.
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- Guest Post: A Philosophical Consideration Of Total Synthesis
This post comes from outside the Baran lab. A very talented undergraduate (Wade Miller) from the University of Pennsylvania sent us his paper from an assignment in philosophy class regarding the relevance of total synthesis in the modern era....
- Academia–industry Collaboration In The Route Optimization Of Taxadienone
In early 2012, we reported the gram-scale synthesis of a non-natural taxane, taxadienone, as well as that of a natural taxane, taxadiene. Now, chemists at Albany Molecular Research Inc. (AMRI) report a route optimization of taxadienone in none other than...
- Ingenol: Behind The Scenes
Disappointment, frustration, excitement, setbacks, thrill, and success. It has been a roller-coaster ride, but finally the reward is here. A total synthesis of ingenol from our lab was published online today. The chemistry is all described in the paper,...
- Woe-be-gone
We'll start things off with our lab's recent synthesis of ouabagenin. We'll skip the biological relevance of the molecule for the purpose of this blog and go straight to the actual synthesis. Read more »...
- Organic Chemistry Problem-solving Approach
NOTES: For each homologous series, there are essentially 3 main areas of focus: Structure & Bonding Physical Properties (Trends) Chemical Properties (Reactions and Mechanism) TYPES OF QUESTIONS: Reactions Synthesis Distinguishing...
Electrochemistry
Column Chromatography....seems silly now.
Last month the team at Eisai responsible for the commercial scale synthesis of Halaven (easily the most complex drug molecule produced entirely by chemical synthesis) published a series of papers (theres three links there) detailing the development from the medchem route to process. While these papers are a must read from the standpoint of using total synthesis to solve a supply need, this post is only peripherally related.
Early on in the synthesis of one of the pieces of the western half of the molecule the group does a chromatographic resolution of a racemic alcohol using 'simulated moving bed chromatography'.
- Guest Post: A Philosophical Consideration Of Total Synthesis
This post comes from outside the Baran lab. A very talented undergraduate (Wade Miller) from the University of Pennsylvania sent us his paper from an assignment in philosophy class regarding the relevance of total synthesis in the modern era....
- Academia–industry Collaboration In The Route Optimization Of Taxadienone
In early 2012, we reported the gram-scale synthesis of a non-natural taxane, taxadienone, as well as that of a natural taxane, taxadiene. Now, chemists at Albany Molecular Research Inc. (AMRI) report a route optimization of taxadienone in none other than...
- Ingenol: Behind The Scenes
Disappointment, frustration, excitement, setbacks, thrill, and success. It has been a roller-coaster ride, but finally the reward is here. A total synthesis of ingenol from our lab was published online today. The chemistry is all described in the paper,...
- Woe-be-gone
We'll start things off with our lab's recent synthesis of ouabagenin. We'll skip the biological relevance of the molecule for the purpose of this blog and go straight to the actual synthesis. Read more »...
- Organic Chemistry Problem-solving Approach
NOTES: For each homologous series, there are essentially 3 main areas of focus: Structure & Bonding Physical Properties (Trends) Chemical Properties (Reactions and Mechanism) TYPES OF QUESTIONS: Reactions Synthesis Distinguishing...