Electrochemistry
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- Guest Post: A Philosophical Consideration Of Total Synthesis
This post comes from outside the Baran lab. A very talented undergraduate (Wade Miller) from the University of Pennsylvania sent us his paper from an assignment in philosophy class regarding the relevance of total synthesis in the modern era....
- Making C–c Bonds With The Simplicity Of Making Amide Bonds
Despite all of the wonderful advances in organic synthesis, amide-bond formation is still the most widely used reaction among those making medicines. This truth has led some to declare their embarrassment and depression. Medicinal...
- Hey! We Used C-h Activation To Make A Natural Product!
Once upon a time, we were interested making fumitremorgin A... Phil's interest in verruculogen and fumitremorgin A has been long standing (see: Austamine and Okaramine), but strangely the endoperoxide-containing indole alkaloids haven't...
- Diterpenoid-alkaloids Are So...fancy (you Already Know)
The second paper on our efforts toward diterpenes and related diterpenoid-alkaloids is out in JACS now. This is building off of work previously published in Angewante last year. The story of this project goes back more than 5 years. ...
- Best Synthesis Evar!
Over at BRSMblog theres a good post on the best synthesis ever. Its a discussion I've had around Baran Lab before, and I figured since total synthesis is our jam, people might have something to contribute to his comment section. I already gave him...
Electrochemistry
Electrochemical Synthesis of Dixiamycins
Phil Baran upon learning about electrochemistry
UPDATE: Our paper was highlighted on Deadspin!
UPDATE 2: Support from the San Diego Chargers!
Our paper on the total synthesis of dixiamycin B is now live in the JACS ASAP section, which means it's my turn to write a blog post. When we initiated this project, we had no idea we'd turn to electrochemistry; we just thought making the N–N bond would be interesting. In fact, I remember it like it was yesterday...
UPDATE 2: Support from the San Diego Chargers!
Our paper on the total synthesis of dixiamycin B is now live in the JACS ASAP section, which means it's my turn to write a blog post. When we initiated this project, we had no idea we'd turn to electrochemistry; we just thought making the N–N bond would be interesting. In fact, I remember it like it was yesterday...
[Professor enters from stage left]
Professor: How would you make this?!
Student: Probably from hydrazine.
Professor: That's not interesting!
[Professor exits stage left]
Read more »
- Guest Post: A Philosophical Consideration Of Total Synthesis
This post comes from outside the Baran lab. A very talented undergraduate (Wade Miller) from the University of Pennsylvania sent us his paper from an assignment in philosophy class regarding the relevance of total synthesis in the modern era....
- Making C–c Bonds With The Simplicity Of Making Amide Bonds
Despite all of the wonderful advances in organic synthesis, amide-bond formation is still the most widely used reaction among those making medicines. This truth has led some to declare their embarrassment and depression. Medicinal...
- Hey! We Used C-h Activation To Make A Natural Product!
Once upon a time, we were interested making fumitremorgin A... Phil's interest in verruculogen and fumitremorgin A has been long standing (see: Austamine and Okaramine), but strangely the endoperoxide-containing indole alkaloids haven't...
- Diterpenoid-alkaloids Are So...fancy (you Already Know)
The second paper on our efforts toward diterpenes and related diterpenoid-alkaloids is out in JACS now. This is building off of work previously published in Angewante last year. The story of this project goes back more than 5 years. ...
- Best Synthesis Evar!
Over at BRSMblog theres a good post on the best synthesis ever. Its a discussion I've had around Baran Lab before, and I figured since total synthesis is our jam, people might have something to contribute to his comment section. I already gave him...